The world is a complex system, and understanding it scientifically requires advanced computational resources and approaches. Engineers design the most powerful computers on Earth in order to model and simulate physical systems such as global climate, the expansion of the universe, and the behavior of matter at an atomic level. But today, high performance scientific computing means more than just supercomputers running numerical models, expanding to large-scale data analysis, AI and machine learning, visualization, and distributed and heterogeneous hardware systems.
UChicago CS researchers are changing the face of high performance computing (HPC), creating new computing paradigms at scale for understanding physical, biological, social, and ecological systems and answering the most significant questions facing society. Faculty lead efforts to apply the latest AI and data science approaches for scientific discovery, from computational imaging and spectroscopy to bioinformatics, neuroscience, and agriculture. In these areas, as well as in the development and application of new exascale systems such as Aurora, UChicago CS benefits from a strong partnership with Argonne National Laboratory.
Labs & Groups
Globus Labs
Large-Scale Systems Group (LSSG)
Chameleon
Center for Translational Data Science
Related Faculty
News & Events

University of Chicago Researchers Revolutionize Network Traffic Generation with AI Breakthrough

Federal budget cuts threaten to decimate America’s AI superiority—and other countries are watching

The Hidden Cost of Netflix’s Autoplay: A Study on Viewing Patterns and User Control

Raul Castro Fernandez among six UChicago scientists awarded prestigious Sloan Fellowships in 2025

Fred Chong from the Department of Computer Science Named ACM Fellow for Contributions to Quantum Computing

Rethinking AI as a Thought Partner: Perspectives on Writing, Programming, and More

UChicago Partners On New National Science Foundation Large-Scale Research Infrastructure For Education

Saturdays with CSIL — How Undergraduates are Transforming CS Education for Local High School Students
